November 8, 2019

New manuscript in submission defining the role of GABA transmission in the neonate.  The answer to the long running question of whether GABA is excitatory early in development may depends.

bioRXiv:  "Regional heterogeneity of developing GABAergic interneuron excitation in vivo"

October 28, 2019

"By measuring the activity through the depth of the cerebral cortex and underlying thalamus, an area which is highly connected to the cortex and often injured around the time of birth, the research team will provide insight into the circuit changes that may underlie human fetal cortical development and inform future studies of brain injury in infants.

“We know from looking at EEGs of infants born pre-term that brain activity takes a big step forward before the time of birth,” Colonnese explained. “This leap in the continuity of brain activity, is probably crucial for consciousness and...

January 24, 2019

While we understand much about the specialized circuits that produce activity in the fetal retina, and the consequences of disruption of that activity for eye and brain outcomes, we know little of the actual brain activity that supports the earliest stages of visual development in the intact animal. Our recent experiments show that early retinal activity is not passively transmitted to the visual cortex. Rather, it is actively amplified and transformed by mechanisms unique to the developing brain. This proposal will use a rodent model of fetal brain development to follow the propagati...

May 1, 2018

Review of thalamocortical stages in sensory development

February 1, 2018

New results on the degree to which retinal waves correlate activity in LGN and V1.

December 7, 2016

Daily changes in the activity of developing mouse cortex until postnatal day (P)24.

October 11, 2016

The study published today in the journal eLIFE describes a unique specialization of the fetal brain for ensuring reliable transmission of early activity.

October 1, 2013

The project, titled “Emergence of Visual Alertness in Cortical Networks,” is focused on understanding how activity and circuit properties change in the cerebral cortex between the fetal and postnatal periods to allow visual awareness at birth.

October 1, 2012

With support from Children's and a gift from Dr Jack and Shirley Kaplan to George Washington University, this study is using a rat model of Fragile X syndrome (FXS) to identify the earliest possible cortical activity deficits in Fragile X syndrome.  The results should inform development of pre-symptomatic EEG based diagnostics for autism in at-risk populations such as very pre-term infants. Identification of the network and synaptic mechanisms of the earliest deficits in cortical processing is important to identify new treatment targets that can be delivered at the appropriate ages....

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A cortico-thalamic 'booster' circuit amplifies and conditions weak sensory inputs to the fetal brain.

October 11, 2016

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© 2016 by MT Colonnese and MA Phillips

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